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Title of experiment: Preparation of 4-(dimethylamino)benzalacetophenone (dimethylaminochalcone) Theoretical background: The synthesis of 4-(dimethylamino)benzalacetophenone involves the condensation reaction between p-dimethylaminobenzaldehyde and acetophenone in the presence of sodium hydroxide. This reaction results in the formation of dimethylaminochalcone, which is a yellow-colored compound. Reaction equation: p-dimethylaminobenzaldehyde + acetophenone → 4-(dimethylamino)benzalacetophenone + H2O Reaction mechanism: The reaction proceeds through a nucleophilic addition-elimination mechanism. The sodium hydroxide acts as a base, deprotonating the acetophenone to form an enolate ion. The enolate ion then attacks the carbonyl carbon of p-dimethylaminobenzaldehyde, leading to the formation of an intermediate. This intermediate undergoes a proton transfer and subsequent elimination of water to yield the final product, dimethylaminochalcone. Experimental Procedure: 1. Set up a 100-mL Erlenmeyer flask with a magnetic stirring bar on a magnetic stirrer. 2. Dissolve 0.02 mole of p-dimethylaminobenzaldehyde and 0.01 mole of acetophenone in 10 mL of 95% ethanol in the flask, with stirring. 3. Once the mixture has completely dissolved, add 5 mL of 10% sodium hydroxide solution. 4. Allow the reaction to proceed for 30 minutes while continuously stirring. 5. After the reaction time, place the flask in an ice bath for 3-5 minutes to cool the reaction mixture. 6. Add 50 mL of ice-cold water to the reaction mixture and let it cool for approximately 5 minutes. 7. Use a clean stirring rod to break the resulting colored precipitate into small pieces. 8. Collect the colored product by vacuum filtration using a Buchner funnel. 9. Wash the product four times with 50 mL of ice-cold water each time while it is on top of the filter paper. 10. Transfer the solid product onto a filter paper and allow it to dry at room temperature for two days. 11. Once dry, measure the weight and melting point of the product. Note: Ensure proper safety precautions are followed throughout the experiment, including the use of appropriate personal protective equipment and working in a well-ventilated area.

Title of experiment: Preparation of 4-(dimethylamino)benzalacetophenone (dimethylaminochalcone)

Theoretical background:
The synthesis of 4-(dimethylamino)benzalacetophenone involves the condensation reaction between p-dimethylaminobenzaldehyde and acetophenone in the presence of sodium hydroxide. This reaction results in the formation of dimethylaminochalcone, which is a yellow-colored compound.

Reaction equation:
p-dimethylaminobenzaldehyde + acetophenone → 4-(dimethylamino)benzalacetophenone + H2O

Reaction mechanism:
The reaction proceeds through a nucleophilic addition-elimination mechanism. The sodium hydroxide acts as a base, deprotonating the acetophenone to form an enolate ion. The enolate ion then attacks the carbonyl carbon of p-dimethylaminobenzaldehyde, leading to the formation of an intermediate. This intermediate undergoes a proton transfer and subsequent elimination of water to yield the final product, dimethylaminochalcone.

Experimental Procedure:
1. Set up a 100-mL Erlenmeyer flask with a magnetic stirring bar on a magnetic stirrer.
2. Dissolve 0.02 mole of p-dimethylaminobenzaldehyde and 0.01 mole of acetophenone in 10 mL of 95% ethanol in the flask, with stirring.
3. Once the mixture has completely dissolved, add 5 mL of 10% sodium hydroxide solution.
4. Allow the reaction to proceed for 30 minutes while continuously stirring.
5. After the reaction time, place the flask in an ice bath for 3-5 minutes to cool the reaction mixture.
6. Add 50 mL of ice-cold water to the reaction mixture and let it cool for approximately 5 minutes.
7. Use a clean stirring rod to break the resulting colored precipitate into small pieces.
8. Collect the colored product by vacuum filtration using a Buchner funnel.
9. Wash the product four times with 50 mL of ice-cold water each time while it is on top of the filter paper.
10. Transfer the solid product onto a filter paper and allow it to dry at room temperature for two days.
11. Once dry, measure the weight and melting point of the product.

Note: Ensure proper safety precautions are followed throughout the experiment, including the use of appropriate personal protective equipment and working in a well-ventilated area.

Added by Jorge T.

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