Question

b. TLC, a powerful analytical tool, can be used to monitor the progress of reactions. The synthesis of ethyl-3-coumarincarboxylate can be monitored by TLC by displaying the starting aldehyde 1, and coumarin product 2, which have very distinct Rf values (Hint: Think about the polarity of compounds 1 and 2 in terms of their abilities to H-bonds to silica gel). i. What can you determine about the progress of the reaction from analysis of the TLC shown below? ii. Calculate the Rf-values for both compounds. iii. Which compound has a larger Rf-value? Explain. Developed TLC of the reaction progress 3.5 cm 2.5 cm co-spot of compounds 1 and 2 1.5 cm

          b. TLC, a powerful analytical tool, can be used to monitor the progress of reactions. The synthesis of ethyl-3-coumarincarboxylate can be monitored by TLC by displaying the starting aldehyde 1, and coumarin product 2, which have very distinct Rf values (Hint: Think about the polarity of compounds 1 and 2 in terms of their abilities to H-bonds to silica gel).

i. What can you determine about the progress of the reaction from analysis of the TLC shown below?

ii. Calculate the Rf-values for both compounds.

iii. Which compound has a larger Rf-value? Explain.

Developed TLC of the reaction progress
3.5 cm
2.5 cm
co-spot of compounds 1 and 2
1.5 cm

b. TLC, a powerful analytical tool, can be used to monitor the progress of reactions. The synthesis of ethyl-3-coumarincarboxylate can be monitored by TLC by displaying the starting aldehyde 1, and coumarin product 2, which have very distinct Rf values (Hint: Think about the polarity of compounds 1 and 2 in terms of their abilities to H-bonds to silica gel).

i. What can you determine about the progress of the reaction from analysis of the TLC shown below?

ii. Calculate the Rf-values for both compounds.

iii. Which compound has a larger Rf-value? Explain.

Developed TLC of the reaction progress
3.5 cm
2.5 cm
co-spot of compounds 1 and 2
1.5 cm

Added by Tina P.

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