to test the relationship between apoe4 and alzheimer's disease , a large number of nursing home patients over the age of 70
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Step 1: Define the Research Question Clearly articulate the research question: "What is the relationship between the presence of the APOE ε4 allele and the incidence or progression of Alzheimer's disease in nursing home patients over the age of 70?" Show more…
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The $\varepsilon 4$ allele of the gene encoding apolipoprotein $E(A P O E)$ is strongly associated with Alzheimer's disease, but its value in making the diagnosis remains uncertain. A study was conducted among 2188 patients who were evaluated at autopsy for Alzheimer's disease by previously established pathological criteria $[16] .$ Patients were also evaluated clinically for the presence of Alzheimer's disease. The data in Table 3.15 were presented. Suppose the pathological diagnosis is considered the gold standard for Alzheimer's disease.What is the specificity of this test?To possibly improve on the diagnostic accuracy of the clinical diagnosis for Alzheimer's disease, information on both the APOE genotype as well as the clinical diagnosis were considered. The data are presented in Table 3.16.
Kirsty G.
Age Group Males Females 65-69 0.016 0.0 70-74 0.00 0.022 75-79 0.049 0.023 80-84 0.086 0.078 85+ 0.35 0.279 Suppose an unrelated 82-year-old man, 72-year-old woman and 77-year-old man are selected from a community. What is the probability that exactly one of the three people has Alzheimer's disease?
David N.
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