Question

Two models have been proposed to understand the formation of the enzyme-substrate complex: 1) the lock & key model, and 2) the induced fit model. Using the figure below, which model of enzyme catalysis better describes how stickase binds the substrate to allow for a reaction to occur? Explain why. (a) No enzyme Substrate (metal stick) Transition state (bent stick) Products (broken stick) S P Free energy, G ?G‡uncat Reaction coordinate (b) Enzyme complementary to substrate Enzyme Magnets ES Few products Free energy, G ?G‡uncat ?G‡cat ?G_M Reaction coordinate (c) Enzyme complementary to transition state E ES P Free energy, G ?G‡uncat ?G_M ?G‡ Reaction coordinate Figure 6-5 Lehninger Principles of Biochemistry, Sixth Edition © 2013 W. H. Freeman and Company

          Two models have been proposed to understand the formation of the enzyme-substrate complex: 1) the lock & key model, and 2) the induced fit model. Using the figure below, which model of enzyme catalysis better describes how stickase binds the substrate to allow for a reaction to occur? Explain why. (a) No enzyme Substrate (metal stick) Transition state (bent stick) Products (broken stick) S P Free energy, G ?G‡uncat Reaction coordinate (b) Enzyme complementary to substrate Enzyme Magnets ES Few products Free energy, G ?G‡uncat ?G‡cat ?G_M Reaction coordinate (c) Enzyme complementary to transition state E ES P Free energy, G ?G‡uncat ?G_M ?G‡ Reaction coordinate Figure 6-5 Lehninger Principles of Biochemistry, Sixth Edition © 2013 W. H. Freeman and Company

Two models have been proposed to understand the formation of the enzyme-substrate complex: 1) the lock key model, and 2) the induced fit model. Using the figure below, which model of enzyme catalysis better describes how stickase binds the substrate to allow for a reaction to occur? Explain why. (a) No enzyme Substrate (metal stick) Transition state (bent stick) Products (broken stick) S P Free energy, G ?G‡uncat Reaction coordinate (b) Enzyme complementary to substrate Enzyme Magnets ES Few products Free energy, G ?G‡uncat ?G‡cat ?GM Reaction coordinate (c) Enzyme complementary to transition state E ES P Free energy, G ?G‡uncat ?GM ?G‡ Reaction coordinate Figure 6-5 Lehninger Principles of Biochemistry, Sixth Edition © 2013 W. H. Freeman and Company

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