Examine a current recording in voltage clamp mode, such as in the figure below. Plot the I-V relationship when the channel is open. Upload a clear screenshot of your plot. Does the channel act like a linear resistor when it is open? What is the single-channel conductance? Enter your answer in pico-Siemens (pS). Estimate and plot the open probability as a function of voltage. Submit a clear image file of your plot. Plot the I-V relationship for the total transmembrane current for a large population of these channels (you can use arbitrary units for the current). Submit a clear image file of your plot. Does the population as a whole act like a linear resistor, that is, when you take into account open probability?
A
0.54 pA
Membrane potential (V.) +30 mV
Open
-Closed
0.18 pA
- Open -Closed
+10 mV
0 mV
-20 mV
-Closed -Open
-0.36 pA -40 mV
-Closed
- Open
-0.72 pA