00:01
Hi all, so here our question is huntington disease, huntington disease which is denoted as hd is a neurogenerative genetic disorder, neurodegenerative genetic disorder, genetic disorder.
00:31
So this involves an autosomal dominant mutant allele with a high penetrance.
00:50
So if a father's mother had this, father's mother had this hd, then what is the probability that his first, first child will have hd? so here the father's mother had this huntington disease and it is caused by this autosomal dominant mutant allele.
01:26
So we can determine the probability of his first child that it inherit the disease.
01:32
So for this we can see that this autosomal, autosomal dominant disorder, for this autosomal dominant disorder, there is a 50 % chance of inheriting the mutant allele, inheriting the mutant allele, 50 % chance of inheriting this mutant allele.
02:02
So since the father's mother had this hd, that is this huntington disease, we can assume that father, father has a 50 % chance of carrying, carrying mutant allele of this hd, for this hd, for hd, that is huntington disease.
02:31
Now let's calculate the probability for the child.
02:35
So we can say that the father's mother have hd...