0:00
Hello.
00:01
So let's answer now the question.
00:02
Let's start with number one.
00:06
So here we are asked, which of the following is the phase -to reaction of xenobiotic metabolism? so here it's about the xenobiotic metabolism.
00:20
So we have the sulfate conjugation.
00:24
So the sulfate conjugation is important part of the phase two.
00:37
It is another important phase -to -reaction that occurs in many xenobiotics.
00:43
So in general, sulfation decreases the toxicity.
00:51
Solvation decreases the toxicity of xenobiotics.
01:12
Unlike the glucuronic acid conjugates that are often eliminated in the bile, the highly polar sulfate conjugates are readily secreted in the urinary.
01:21
That's why it will decrease the toxicity of the xenobiotics.
01:26
Let's say for this question, since we have the sulfate conjugation as important phase -to -reaction in many xenobiotic, then our answer here is we have conjugation.
01:42
So our answer for number one is we have conjugation...