What interaction with acidic drugs affects the extent of drug distribution?What interaction with basic drugs affects the extent of drug distribution?
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Drugs that are predominantly unionized (uncharged) at physiological pH (7.4) will have more extensive distribution when compared to drugs that are ionized (charged).
Supreeta N.
Which of the following is not considered a fundamental component of pharmacokinetics? - Drug elimination - Drug absorption - Down regulation of drug receptors - Drug distribution - Drug metabolism In an obese patient, would the dose of a fat-soluble drug be increased or decreased, and why? - Decreased due to added stress on the kidneys - Increased due to slow rate of absorption - Decreased due to lower amounts bound to serum proteins - Decreased due to the weight of the individual - Increased due to an increase in the volume of distribution
Adi S.
A drug contains an ionized carboxylate group and shows good activity against its target in in vitro tests. When in vivo tests were carried out, the drug showed poor activity when it was administered orally, but good activity when it was administered by intravenous injection. The same drug was converted to an ester, but proved inactive in vitro. Despite that, it proved to be active in vivo when it was administered orally. Explain these observations.
Sri K.
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