Which monarch suffered a serious nose bleed at the Bishop's Palace in Salisbury in 1688?
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Queen Victoria's daughter Alice married Louis IV and produced seven children. What percentage of their daughters were carriers? What percentage of their sons had hemophilia? How does this compare with what would be expected for female and male offspring of a carrier mating with a normal male? How was hemophilia transferred through the royal families in this pedigree?
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Now for the Spanish connection: Victoria's youngest child, Beatrice, gave birth to one daughter, one normal son, and two hemophilic sons. Looking at the pedigree of the royal family, identify which of Beatrice's children received the hemophilic gene. Why can you make this conclusion? Notice that Beatrice's daughter, Eugenie, married King Alfonso XIII of Spain and had six children, one of whom was the father of Juan Carlos, the current King of Spain. Would you predict that Juan Carlos was normal, a carrier, or hemophilic?
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In 1995, a sixty-three year old man named Eugene Romanov, a resident of the former Soviet Union, turned up. He shared both the disease and his last name with the royal family of czarist Russia. He proclaimed himself a grandson of Nikolas II's youngest daughter, Anastasia, whose body had never been recovered and was believed by some to have managed to survive the revolution. Eugene Romanov claimed Anastasia was raised by a farmer, and later she married a nephew of her adopted parents and had a daughter, Eugene's mother. a) According to Eugene's argument, what was the likely hemophilic status of Eugene's mother and grandmother? What about his father and grandfather? Is this argument plausible? b) How plausible is it that Eugene inherited both hemophilia and the last name from the royal family? (Hint: Look how each of them is passed from generation to generation.)
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