Which ONE of the following statements is TRUE?
A. Volume of distribution relates the concentration of drug in tissues to the plasma concentration.
B. Volume of distribution is the sum of plasma extracellular and intracellular fluid volume.
C. An increase in volume of distribution of a drug will cause an increase in clearance of a drug.
D. Volume of distribution can be used to calculate the maintenance dose of a drug.
E. An increase in volume of distribution will cause an increase in elimination half-life of a drug.