00:01
Everyone in this question we will be discussing about the complement system which are basically the cell surface protein or glycoprotein and these are both innate and antibody mediated acquired immunity so there are different components of the complement system like c1 has c1 q which is the which has the receptor for fc of the antibody.
00:33
Then c1r is serene protease and there is c1s that cleaves further.
00:40
Then we have c2 which has c2a as the large subunit and c2b as the small subunit.
00:53
And then we have c3 in which it is small and c3 b is large.
01:05
Then we have c4 in which also c4a is small and c4b is large.
01:17
And then we have c5 which is c5a is small and the the c -5 is large.
01:27
So here the small subunit diffuse from the site and initiate the localized inflammatory response in all the subunits, whereas the larger subunits bind to the target side.
01:45
So in the classical pathway, it begins with formation of the antigen, and antibody complexes and this is their humoral adapt.
01:59
So first of all the antigen antibody complex will bind to c1 and then it will activate the serene protease activity of this c1 will activate the c4 and the c4a that is the small subunit will diffuse out and the c4b will go on the target that is the c2 and the c2b that is the small subunit of c2 will diffuse out and the c2a will hit the target.
02:34
So here we have the antigen antibody plus c2a plus c4b plus c1 is there that is known as the c3 convertase.
02:50
Then we have the second that is the lectin pathway.
02:56
In this, the lectin binds to the specific carbohydrate target and it is activated by manus residue of glycoprotein or polysaccharide on the surface of bacteria.
03:10
So here let us say that the bacterial protein with polysaccharide with terminal manose residue x binds with the manus binding lectin and also there is masp 1 plus masp 2 that is mbl associated serene protease and this masp 2 can cleave both the c2 as well as the c4 so it will cleave the c4 and c4a will diffuse out and then c4 we will move and the c2 will also be cleave in which the c2 will be cleave out.
03:55
So here x plus c4b plus c2a plus mbl plus masp 1 plus mas gives the c3 convertase.
04:10
Then we have the alternative properine pathway which is antibody independent in it is triggered by any foreign substances so here the c3 hydrolysis takes place in which the c3a will move out and we will have c3 b which will bind to the foreign substance and now this c3 b will bound to factor b and then to factor d which will leave it and the b a subunit.
04:57
This factor d will cleave the b factor and the b a subunit at the small subunit will diffuse out and the b subunit will remain...