Question

Why does the entropy of the system increase when proteins fold in water? In an unfolded polypeptide, a large number of water molecules become ordered around hydrophobic regions. These water molecules are free to once these hydrophobic regions are brought together in the folded conformation of the protein. This in disorder of the water molecules overcomes the fact that the folded polypeptide has attained a conformation.

          Why does the entropy of the system increase when proteins fold in water?

In an unfolded polypeptide, a large number of water molecules become ordered around hydrophobic regions. These water molecules are free to once these hydrophobic regions are brought together in the folded conformation of the protein. This in disorder of the water molecules overcomes the fact that the folded polypeptide has attained a conformation.

Why does the entropy of the system increase when proteins fold in water?

In an unfolded polypeptide, a large number of water molecules become ordered around hydrophobic regions. These water molecules are free to once these hydrophobic regions are brought together in the folded conformation of the protein. This in disorder of the water molecules overcomes the fact that the folded polypeptide has attained a conformation.

Added by Renee P.

Chemistry: Structure and Properties

Nivaldo Tro 2nd Edition

Instant Answer

Solved by Expert Dominador Tan

01/20/2022

Step 1

In an unfolded protein, the hydrophobic regions are exposed to water. Water molecules form a structured, ordered shell around these hydrophobic regions, which is a low entropy (highly ordered) state. Show more…

Show all steps

Thanks for your feedback!

Why does the entropy of the system increase when proteins fold in water? In an unfolded polypeptide, a large number of water molecules become ordered around hydrophobic regions. These water molecules are free to move when these hydrophobic regions are brought together in the folded conformation of the protein. This increase in disorder of the water molecules overcomes the fact that the folded polypeptide has attained a more ordered conformation.