STEP-BY-STEP ANSWER:
Step 1: Understand that microevolution involves small genetic changes within a population over time through mutation, genetic drift, and gene flow.
Step 2: Recognize that when these changes accumulate, they can significantly alter the genetic makeup of a population.
Step 3: Identify that reproductive isolation mechanisms, such as geographic separation (allopatric speciation) or ecological differences (sympatric speciation), prevent gene flow between populations.
Step 4: Conclude that due to the absence of genetic exchange, the isolated populations diverge further, eventually resulting in the formation of distinct species.
Final Answer: The gradual accumulation of microevolutionary changes, coupled with reproductive isolation, leads to speciation.