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Essential Cell Biology

Bruce Alberts, Karen Hopkin, Alexander D. Johnson

Chapter 19

Sexual Reproduction and Genetics - all with Video Answers

Educators


Chapter Questions

05:38

Problem 1

Why do you think that organisms do not use the first steps of meiosis (up to and including meiotic division I) for the ordinary mitotic division of somatic cells?

Bryan Valdivia
Bryan Valdivia
Numerade Educator
02:41

Problem 2

Ignoring the effects of chromosome crossovers, an individual human can in principle produce $2^{23}=8.4 \times 10^{6}$ genetically different gametes. How many of these possibilities can be sampled" in the average life of
(A) a female and (B) a male, given that women produce one egg a month during their fertile years, whereas men can make hundreds of millions of sperm each day?

Angelos Evangelinos
Angelos Evangelinos
Numerade Educator
06:26

Problem 3

Imagine that each chromosome undergoes one and only one crossover event on each chromatid during each meiosis. How would the co-inheritance of traits that are determined by genes at opposite ends of the same chromosome compare with the co-inheritance observed for genes on two different chromosomes? How does this compare with the actual situation?

Sana Riaz
Sana Riaz
Numerade Educator
11:22

Problem 4

When two individuals from different isolated, inbred subpopulations of a species come together and mate, their offspring often show "hybrid vigor": that is, they appear more robust, healthy, and fertile than either parent. Can you suggest a possible explanation for this phenomenon?

Sana Riaz
Sana Riaz
Numerade Educator
06:51

Problem 5

In a recent automated analysis, thousands of SNPs across the genome were analyzed in pooled DNA samples from humans who had been sorted into groups according to their age. For the vast majority of these sites, there was no change in the relative frequencies of different variants as these humans aged. Sometimes, albeit rarely, a particular variant at one position was found to decrease in frequency progressively for people over 50 years old. Which of the possible explanations seems most likely?
A. The nucleotide in that SNP at that position is unstable, and mutates with age.
B. Those people born more than 50 years ago came from a population that tended to lack the disappearing SNP variant.
C. The SNP variant alters an
important gene product in a way that shortens the human life-span, or is linked to a neighboring allele that has this effect.

Sana Riaz
Sana Riaz
Numerade Educator
12:22

Problem 6

It is easy to see how deleterious mutations in bacteria, which have a single copy of each gene, are eliminated by natural selection: the affected bacteria die and the mutation is thereby lost from the population. Eukaryotes, however, have two copies of most genes-that is, they are diploid. Often an individual with two normal copies of the gene (homozygous normal) is indistinguishable in phenotype from an individual with one normal copy and one defective copy of the gene (heterozygous). In such cases, natural selection can operate only against an individual with two copies of the defective gene (homozygous defective). Consider the situation in which a defective form of the gene is lethal when homozygous, but without effect when heterozygous. Can such a mutation ever be eliminated from the population by natural selection? Why or why not?

Sana Riaz
Sana Riaz
Numerade Educator
01:44

Problem 7

Which of the following statements are correct? Explain your answers.
A. The egg and sperm cells of animals contain haploid genomes.
B. During meiosis, chromosomes are allocated so that each germ cell obtains one and only one copy of each of the different chromosomes.
C. Mutations that arise during meiosis are not transmitted to the next generation.

Angelos Evangelinos
Angelos Evangelinos
Numerade Educator
02:13

Problem 8

What might cause chromosome nondisjunction, where two copies of the same chromosome end up in the same daughter cell? What could be the consequences of this event occurring (a) in mitosis and (b) in meiosis?

Anand Jangid
Anand Jangid
Numerade Educator
02:13

Problem 8

What might cause chromosome nondisjunction, where two copies of the same chromosome end up in the same daughter cell? What could be the consequences of this event occurring (a) in mitosis and (b) in meiosis?

Anand Jangid
Anand Jangid
Numerade Educator
04:33

Problem 9

Why do sister chromatids have to remain paired in division 1 of meiosis? Does the answer suggest a strategy for washing your socks?

Bryan Valdivia
Bryan Valdivia
Numerade Educator
03:30

Problem 10

Distinguish between the following genetic terms:
A. Gene and allele.
B. Homozygous and heterozygous.
C. Genotype and phenotype.
D. Dominant and recessive.

Angelos Evangelinos
Angelos Evangelinos
Numerade Educator
06:07

Problem 11

You have been given three wrinkled peas, which we shall call $A, B,$ and $C,$ each of which you plant to produce a mature pea plant. Each of these three plants, once self-pollinated, produces only wrinkled peas.
A. Given that you know that the wrinkled-pea phenotype is recessive, as a result of a loss-of-function mutation, what can you say about the genotype of each plant?
B. How do you determine if each of the three plants carries a mutation in the same gene or in different genes that produce the phenotype?

Bryan Valdivia
Bryan Valdivia
Numerade Educator
06:08

Problem 11

You have been given three wrinkled peas, which we shall call $\mathrm{A}, \mathrm{B},$ and $\mathrm{C},$ each of which you plant to produce a mature pea plant. Each of these three plants, once self-pollinated, produces only wrinkled peas.
A. Given that you know that the wrinkled-pea phenotype is recessive, as a result of a loss-of-function mutation, what can you say about the genotype of each plant?
B. How do you determine if each of the three plants carries a mutation in the same gene or in different genes that produce the phenotype?

Bryan Valdivia
Bryan Valdivia
Numerade Educator
12:01

Problem 12

Susan's grandfather was deaf, and passed down a hereditary form of deafness within Susan's family as shown in Figure $019-12$
A. Is this mutation most likely to be dominant or recessive?
B. Is it carried on a sex chromosome? Why or why not?
C. A complete SNP analysis has been done for all of the 11 grandchildren (4 affected and 7 unaffected). In comparing these 11 SNP results, how long a haplotype block would you expect to find around the critical gene? How might you detect it?

Sana Riaz
Sana Riaz
Numerade Educator
02:20

Problem 13

Given that the mutation causing deafness in the family shown in Figure $19-26$ is very rare, what is the most probable genotype of each of the four children in generation II?

Angelos Evangelinos
Angelos Evangelinos
Numerade Educator
10:44

Problem 14

In the pedigree shown in Figure $019-14$, the first born in each of three generations is the only person affected by a dominant genetically inherited disease, D. Your friend concludes that the first child born has a greater chance of inheriting the mutant $D$ allele than do later children.
A. According to Mendel's laws, is this conclusion plausible?
B. What is the probability of obtaining this result by chance?
C. What kind of additional data would be needed to test your friend's idea?
D. Is there any way in which your friend's hypothesis might turn out to be right?

Bryan Valdivia
Bryan Valdivia
Numerade Educator
05:53

Problem 15

Suppose one person in 100 is a carrier of a fatal recessive mutation, such that babies homozygous for the mutation die soon after birth. In a population where there are 1,000,000 births per year, how many babies per year will be born with the lethal homozygous condition?

Bryan Valdivia
Bryan Valdivia
Numerade Educator
05:24

Problem 16

Certain mutations are called dominant-negative mutations. What do you think this means and how do you suppose these mutations act? Explain the difference between a dominant-negative mutation and a gain-of-function mutation.

Bryan Valdivia
Bryan Valdivia
Numerade Educator
02:54

Problem 17

Early genetic studies in Drosophila laid the foundation for our current understanding of genes. Drosophila geneticists were able to generate mutant flies with a variety of easily observable phenotypic changes. Alterations from the fly's normal brick-red eye color have a venerable history because the very first mutant found by Thomas Hunt Morgan was a white-eyed fly (Figure $Q 19-17$ ). since that time, a large number of mutant flies with intermediate eye colors have been isolated and given names that challenge your color sense: garnet, ruby, vermilion, cherry, coral, apricot, buff, and carnation. The mutations responsible for these eyecolor phenotypes are all recessive. To determine whether the mutations affected the same or different genes, homozygous flies for each mutation were bred to one another in pairs and the eye colors of their progeny were noted. In Table $Q 19-17$, a $+$ or a - indicates the phenotype of the progeny flies produced by mating the fly listed at the top of the column with the fly listed to the left of the row; brick-red wild-type eyes are shown as $+$ and other colors are indicated as - .
A. How is it that flies with two different eye colors-ruby and white, for example-can give rise to progeny that all have brick-red eyes?
B. Which mutations are alleles of the same gene and which affect different genes?
C. How can different alleles of the same gene give different eye colors?

Rabeya Zahid
Rabeya Zahid
Numerade Educator
02:37

Problem 18

What are single-nucleotide polymorphisms (SNPs), and how can they be used to locate a mutant gene by linkage analysis?

Bryan Valdivia
Bryan Valdivia
Numerade Educator