Book cover for Fundamentals of Biostatistics

Fundamentals of Biostatistics

Bernard Rosner

ISBN #9781305268920

8th Edition

1,397 Questions

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Homework Questions

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Summary

Learning Objectives

Key Concepts

Example Problems

Explanations

Common Mistakes

Summary

Nonparametric methods provide flexible and robust alternatives to parametric tests, especially when the assumption of normality is violated or when data are inherently ordinal or categorical. Key tools include the sign test, Wilcoxon signed?rank test for paired data, and the Wilcoxon rank?sum test for independent samples, with permutation tests serving as exact methods for small or tied data. Understanding when to apply these methods—based on data type and study design—is crucial for valid statistical inference in fields such as medicine, biology, and social sciences.

Learning Objectives

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Key Concepts

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Example Problems

Example 1

Assess the impact of the program statistically (use a two-sided test). Suppose patients are graded on the degree of change in periodontal status on a 7 -point scale, with +3 indicating the greatest improvement, 0 indicating no change, and -3 indicating the greatest decline. The data are given in Table 9.9

Example 2

What non-parametric test can be used to determine whether a significant change in periodontal status has occurred over time?

Example 3

Implement the procedure in Problem 9.2, and report a $p$ -value.

Example 4

Suppose there are two samples of size 6 and $7,$ with a rank sum of 58 in the sample of size $6 .$ Using the Wilcoxon rank-sum test, evaluate the significance of the results, assuming there are no ties.

Example 5

Answer Problem 9.4 for two samples of size 7 and 10, with a rank sum of 47 in the sample of size 7 . Assume there are no ties.

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Step-by-Step Explanations

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Common Mistakes

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