Benzodiazepine sedative hypnotics anxiolytics: (pam and lam suffix)
Action= increases GABA; causes sedation and can lead to dependence
ANTICHOLINERGIC EFFECTS- NO 3S's
Don't take w alcohol, high potential for abuse and taper off
B-no Booze A-Abuse E- encrementally taper off
Alprazolam-
Diazepam- Lorazepam- Chlordiazepoxide-
Clonazepam-
Oxazepam-
Antihistamine: A ANTICHOLINERGIC EFFECTS- NO 3S's
Hydroxyzine- potent and highly-selective histamine inverse agonist
Atypical Anxiolytics:
Buspirone-
Inc serotonin, dizziness, insomnia, ANTICHOLINERGIC EFFECTS- NO 3S's
SSRIs (selective serotonin reuptake inhibitors): pram, tine
S- suicide risk
S- slow onset, taper off
SEROTONIN SYNDROME:
S-sweaty and hot (fever)
R- rigid muscles- hyperreflexia, restlessness, agitation, confusion, hallucinations I- increased HR and BP (tachycardia) (hypertension)
Action= inhibits reuptake of serotonin (therefore serotonin IvIs inc)
AE= wt gain, sexual dysfunction, insomnia,
Never mix SSRIs w St Johns wort, or MAOIs!!!
Paroxetine- Sertraline- Citalopram- Escitalopram- Fluoxetine- Fluvoxamine-
SNRIs (serotonin-norepinephrine reuptake inhibitors): VDD
Action= increase levels of norepi and 5HT and serotonin
AE=
Venlafaxine.
Duloxetine- DUAL purpose- depression and px Desvenlafaxine-
Clonidine/propranolol- used for sx control, any physical manifestations of anxiety; inc
HR, palpitations
Flumazenil: reversal for benzos