Lehninger PRINCIPLES of BIOCHEMISTRY Seventh Edition
14| Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
O 2017 W. H. Freeman and Company
David L.Nelson Michael M.Cox
CHAPTER 14
Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
Learning goals: Harnessing energy from glucose via glycolysis Fermentation under anaerobic conditions Synthesis of glucose from simpler compounds: gluconeogenesis
Glycolysis: Overview
Functions of glycolysis: 1. In the absence of terminal electron acceptors (oxygen) glycolysis provides all the ATP required for cellular activity 2. Glycolysis intermediates are direct precursors of many cellular building blocks: All the amino acids Membrane lipids Nucleotides in DNA and RNA Cofactors needed for the metabolism 3. Pyruvate product feeds into TCA or is fermented in the absence of oxygen
Extracellularmatrix andcellwall polysaccharides
Glycogen, starch, sucrose
synthesis of structural polyme
torage
Glucose oxidation via glycolysis
oxidation via pentose phosphat pathway
Ribose 5-phosphate
Pyruva