Bio220 Aut 2022 Unit 3, Carbon Dioxide Transport
Learning Objectives Use flow diagrams to explain how CO2 moves from body tissues to the blood (stored as HCO3) and then from HCO3" in blood to the air in lungs.
2. Use Le Chatelier's principle to explain changes in the rate or direction of production of CO2 or HCO3 based on changes in concentrations of reactants or products.
3. Understand the relative measures of Pco2 in the atmosphere, alveolar space, pulmonary capillaries, systemic arterial blood, capillaries in body tissues, systemic venous blood
Vocabulary Thoracic Cavity Lungs Trachea and other tubes Alveoli Capillaries Arteries Veins Working tissue cells Red blood cell (RBC) lons Protons (H*) Bicarbonate (HCO3) Other molecules Carbonic Acid (H2CO3) Gases 0 Oxygen, O2 Carbon dioxide, CO2 Transport proteins HCO3-/Cl exchanger Enzymes Carbonic Anhydrase
Practice Questions
A human, at sea level and at rest, has the following blood PcO2 measurements, with one missing for you to fill in. Pulmonary artery Pulmonary vein Systemic artery Systemic vein 45 20 20
For each of the following changes from normal/rest, how will things change? (Use flux or mass balance reasoning.) person becomes active PcO2 in systemic vein How? higher, lower, or no change reduced carbonic anhydrase PCOz in systemic vein How? activity higher, lower, or no change more red blood cells per flux of COz from body How? volume of blood tissues to systemic vein increases, decreases, stays the same increased number of flux of CO2 to lungs How? bicarbonate-chloride increases, decreases, exchangers in red blood cell stays the same membranes
2. Where in the circulatory system of a human are the following in chemical equilibrium? oxyhemoglobin reaction: bicarbonate reaction:
Where in the circulatory system of a human are the following not in chemical equilibrium? oxyhemoglobin reaction: bicarb reaction:
Explain your reasoning. MAX two reasonable length sentenc