HS 2211 - Human Anatomy and Physiology Discussion Forum Unit 2 Skeletal System Article Review Using the external resource of PubMed (https://www.ncbi.nlm.nih.gov/pubmed/), find an article that identifies a clinical disorder that represents a fundamental disturbance of the structural integrity (anatomy) of bone tissue or the skeletal system. Introduce the clinical disorder, describe the impact on community health, and demonstrate your understanding of the material presented in Chapters 6-9. Correctly define and use at least 4 anatomic terms related to the structural organization of bone tissue or skeletal system of humans as related to the clinical scenario you introduce to your readers. Your Discussion must be at least 250 words in length, detailing your thoughts and position using 2 references from the readings for support. Also be sure to pose 1-2 well thought out questions from which your colleagues can formulate a response or generate further discussion. Be sure to cite any references using APA format.
Introduce the clinical disorder: Paget's Disease Paget's disease is one of the most common focal bone diseases that occur in adults over the age of 50 years old (Bertoldi et al., 2014). The disease is either symptomatic or asymptomatic (Shaker, 2009). Some manifestations
of Paget's disease are anatomical deformities, bone pain, fractures, and other complications in the structural integrity of the patient (OpenStax, 2018). The human bone is constantly reforming and remodeling itself as old or damaged bones are dissolved for repair (OpenStax, 2018). The osteoclast is the bone cell that is responsible for bone resorption in the remodeling process (OpenStax, 2018). In patients with Paget's disease, the cell involved in this remodeling process is overly active. The increase in the number and size of osteoclasts causes an abnormal speed of bone resorption which increases the activation of osteoblast, which is responsible for bone formation (OpenStax, 2018). The acceleration in bone formation is done in a disorganized manner and the bone that is laid down as a result is "mechanically insufficient" and is at risk for deformity or fracture (Shaker, 2009). Although it is understood that Paget's disease is a disease of the osteoclasts, the exact cause of this overactivation is not yet known. Some postulate that environmental factors such as the Paramyxovirus may be a contributing factor to the development of Paget's disease (Shaker, 2009). Others theorize a relationship between the ownership of non-vaccinated dogs and the development of the disease (Shaker, 2009). These theories are however not yet definitive. Aside from this, some suggestions indicate that genetics might play a role in the incidence of Paget's disease (Shaker, 2009). Patients with the disease tend to have a history of the disease in relatives.