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Virus Replication and Infection Outcomes

Chapter 3. General Features of the Virus Replication Cycle - Part II In cells, the central dogma for genetic information flow is: transcription translation > RNA - > protein replication Describe the genetic information flow for viruses that have a DNA genome. Describe the genetic information flow for viruses that have an RNA genome. Describe the genetic information flow for retroviruses. For a DNA virus that replicates in the cytoplasm of the host cell, what is the one enzyme it must have packaged in its capsid to ensure its replication in the host cell? What enzyme is also likely to be present? For an RNA virus that replicates in the cytoplasm of the host cell, what is the one enzyme it must encode in its genome to ensure its replication in the host cell? Why does the virus need this particular enzyme? What type of RNA virus must package that enzyme in its capsid to ensure its replication in the cell, and why? Chapter 4. Virus Cultivation; Outcomes of Infection Different viruses are capable of establishing infections resulting different outcomes for the host cell. Fill in the following table that examines the different outcomes of viral infections. Type of infection Acute (lytic) Persistent Latent Oncogenic Type of virus naked or enveloped) Viral genome RNA, DNA or retrovirus) Does the viral genome integrate into host? Immediate fate of infected cell