WORKSHOP: 1. Identify the pathophysiological changes in the kidney that result in proteinuria and reduced GFR. Hypertension causes damage to glomeruli, leading to large proteins filtering into the filtrate. Furthermore, the venal tubules are damaged- Impairs reabsorption of proteins thus We see proteins present in urine 2. What are Jane's modifiable and non-modifiable risk Factors For chronic kidney disease? Modifiable . Diet ( healthier) · Alcohol · Weight (obesity) · Smoking · Physical exercise · Medication (stressing inducing) Non- Modifiable · Type 2 diabetes mellitus . Genetic factors Hypertension · Dyslipidemia (hypertipodimic) · Age Ethnicity · family history 3. How does her hypertension relate to her renal Function? (Consider: Is her hypertension causing her altered renal Function or is it a result of her altered renal Function?) Hypertension Both : damage to renal arteries · Atherosclerosis 4 fenestrations in glomeruli enlarge 4 narrowing of vesels impaired filtration ( protein -albumin, into filtrate) Lo ischemia - Into the ronal tubules Linodeque activation of RAAS = Proteinuria + destruction of nephrons 4. Draw a diagram of the venin-angiotensin-aldosterone (RAAS) pathway involved in the maintenance of blood pressure. Make sure to include the key organs as well the enzymes involved in thus pathway. reduced renal perfusion Stimulus: A release of renin B angiotensin 2 (converted by ACE) C angiotensinagen is released D angiotension 1 (converted by renin ) F ACE (angiotertain converting enzyme) E systemic arteriales adveral glands hypothalamus G vasoconstriction O aldodorme Stretien H Na+ +H20 rentention elevated thirst M K posterior pituitary N Island 0 antidieactic hormone ( vasadepres) P increased blood pressure