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Acute Kidney Injury and Chronic Kidney Disease: Oxidative Stress and Inflammation

Integrated Physiology and Pathophysiology Kidney Module for BIOM3015 Lecture 3 Acute kidney injury, chronic kidney disease, applying roles of oxidative stress and inflammation Assoc Prof Glenda Gobe g.gobe@uq.edu.au Copyright 2022 Themes of Lecture 3 Acute kidney injury (AKI) · How do we define AKI and how does it occur? · How important is AKI? • Why and how do kidney cells die during AKI (esp. via mitochondrial/oxidative stress)? · Can & do kidneys recover? Chronic kidney disease (CKD) • Why is there a tendency for AKI to progress to CKD? . How important is CKD? How can we apply knowledge of causes to treatment for CKD? How do we define AKI and how does it occur? How important is AKI?