LECTURE: DIABETES MELLITUS WEEK: 4 BLOOD GLUCOSE HOMEOSTASIS INSULIN · Secreted From pancreatic beta B cells . Increases uptake of glucose into cells and conversion into glycogen . Increases uptake of Fatty acids into cells · Secretion is stimulated mainly by increased blood glucose GLUCAGON . Secreted From pancreatic Alfa a cells " In the liver it causes : Gluconeogenesis Breakdown glycogen (stored Form of glucose ) In adipose tissue it causes: Lipolysis Decreased blood glucose stimulate secretion EFFECTS OF INSULIN ON TARGET CELLS Blood Insulin Receptor - Glucose Insulin Sone insulin binds to the insulin receptor Blood Insulin Glucose Stwo More GLUT4 transporters are inserted into the cell membrane Insulin Receptor Glucose transporter Blood Three Sont Glucose enters the cell Insulin Receptor Insulin 1 Glucose Glucose is used by the cell OTHER EFFECTS OF INSULIN ON TARGET CELLS Speeds oh conversion of glucose to glycogen Speeds of protein and Fat synthesis Note: some cells don't require GLUT4 For example: Brain, red blood cells, kidney, lens This is because glucose into that a constant rate