I believe this study was ethically sound and in line with a utilitarian approach to experimentation. The use of human subjects in this study stands to greatly benefit psychiatric research. With veteran suicide incidence increasing (Australian Institute of Health and Welfare, 2020) by exploring novel approaches, as a society, we can hope to tackle this mental health crisis. This study found that psychedelic therapies may be a rapid-acting and novel treatment of PTSD and related mental health symptoms in U.S Special Operations Forces (SOF) veterans, as opposed to current treatment methods that are proving ineffective in treating this unique population. Over 3 years, 51 SOF veterans were administered both Ibogaine Hydrochloride (orally) and 5-MeO-DMT (inhaled) over 3 days. Subjects were asked to complete a self- retrospective survey one month before and after the program asking them to rank the severity and frequency of PTSD and other symptoms. Researchers concluded that there was evidence (p<0.001) supporting their hypothesis that subject surveys would reflect a significant reduction in severity across the mental health domains, with 96% of participants reporting acute improvement in symptoms. This study was approved by an independent human subject's review panel at Solutions Institutional Review Board. Referred by word of mouth, all participants were volunteers. So before enrolling in the program, medical screening was used to determine eligibility and potential contraindications. While discussing limitations, it was mentioned that the study lacked gold standard clinical administered assessment for mental health or cognitive impairment. Researchers relied on previous diagnoses and perceived changes in mental health and cognitive functioning. To combat potential risk, researchers exercised caution and excluded those with specific psychotic spectrum disorders and those on medications that had the potential to cause harm, e.g., serotonin toxicity when psychedelic substances interact with anti-depressants (Malcom and Thomas, 2021). Upon review, I believe the participants were provided with adequate informed consent. They were provided with clear information on the benefits, and potential adverse effects associated with taking these substances. Hosting preparation sessions before each drug was administered, provided opportunity for participants to enquire about concerns they had. I believe the administration of the psychoactive substances was performed ethically as they were given on separate days, with adequate time between for the subjects to process and rest. Although there would be opportunity and temptation to manipulate results either by data trimming or altering survey response, I don't believe that it would be in the researchers' best interest, nor that it has occurred, as funding was provided by The Mission Within organisation which specialises in innovative treatment for conditions that occur during military service (The Mission Within, 2021). Neither substance used is FDA approved as they are Schedule 1 restricted drugs, hence the necessity to host the study in Mexico where they are unscheduled. Each patient was provided contact information for coping assistance throughout and after the experience. I believe this was a valuable ethical decision, as there is a potential risk for people to seek these substances for self-medication. I believe it would be