Module Code: BIO00071H Examination Candidate Number: UNIVERSITY of York BSc Degree Examinations 2020-21 Department: BIOLOGY Title of Exam: Advanced topics in Molecular biology Time Allowed: 24 Hours (PLEASE NOTE: Late papers will not be marked)* *Submissions up to 30 minutes late will be marked but will receive a 5% mark penalty. *Submissions 30 minutes late or more will not be marked and will be considered a non-submission. Time Recommended: 2.5 hours The recommended time indicates how long it would take to do the assessment if you were able to focus on it in typical 'exam-type' conditions. Additional guidance is available here. Word limit: Please answer the questions within the line limit stated. Content beyond the line limit will not be marked. Allocation of Marks: Total marks available for this paper: 100 The marks available for each question are indicated on the paper. Instructions for Candidates: All questions should be answered on this question paper using minimum font size Arial 11. Each question should be answered within the stated line limit. Do not adjust the margin width. 1
Module Code: BIO00071H A note on Academic Integrity We are treating this online examination as a time-limited open assessment, and you are therefore permitted to refer to written and online materials to aid you in your answers. Please note that verbatim copying of lecture material and published sources is plagiarism. You must ensure that the work you submit is entirely your own, and for the whole time the assessment is live you must not: · communicate with other students on the topic of this assessment. · communicate with departmental staff on the topic of the assessment (other than to highlight an error or issue with the assessment which needs amendment or clarification). . seek assistance with the assessment from academic support services, such as the Writing and Language Skills Centre or Maths Skills Centre, or from Disability Services (unless you have been recommended an exam support worker in a Student Support Plan). · seek advice or contribution from any other third party, including proofreaders, friends, or family members. We expect, and trust, that all our students will seek to maintain the integrity of the assessment, and of their award, through ensuring that these instructions are strictly followed. Where evidence of academic misconduct is evident this will be addressed in line with the Academic Misconduct Policy and if proven be penalised in line with the appropriate penalty table. Given the nature of these assessments, any collusion identified will normally be treated as cheating/breach of assessment regulations and penalised using the appropriate penalty table (see AM3.3. of the Guide to Assessment). 2
Module Code: BIO00071H Part A (40 marks) Questions based on Iserman et al. (2020). Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production. Cell 181, 818-831. 1. What is the evidence in this paper that Ded1p is part of Stress Granules (SG)? (2 marks, 2 lines) Figure 2A (1) shows that Ded1p colocalises with a marker of SG (Pab1p)