STUDENT LEARNING OBJECTIVES Chromosomal Basis of Inheritance Make sure you know the following: · Understand the study by Thomas Hunt Morgan that involves Drosophila melanogaster (fruit fly) o Know the definitions of wild-type and mutant · Define recombinant phenotype · Define linked genes (do not assort independently of each other) and unlinked genes (assort independently of each other) · Define incomplete linkage · Be able to determine the phenotypic ratio when looking at the two genes that are completely linked and unlinked . Explain why males are more likely to inherit sex-linked disorders compared to females NOTE - Females can be carriers for sex-linked traits (not males) ... also, males and females can both be carriers for autosomal traits . Be familiar with examples of human sex-linked disorders that were provided in lecture · Define non-disjunction, aneuploidy, monosomy and trisomy o Know the examples of human aneuploid conditions given in lecture (and be able to identify karyotypes associated with each of these conditions ... note that karyotypes were covered in an earlier lecture topic) · Know that cri du chat is a human syndrome based on a structural alteration in one of the chromosomes (a specific deletion in chromosome 5) . Be able to do Punnett squares of a cross with one trait that is sex-linked gene . Be able to do Punnett squares of a cross with two traits (with one gene being autosomal and other gene being sex-linked)