Question

A protein complex in the nucleus is responsible for transporting mRNA molecules into the cytoplasm. Describe the proteins that form this exporter. What two protein groups are likely behind the mechanism involved in the directional movement of the mRNP and exporter into the cytosol.

Name: Problem 9, Chapter 8: Molecular Cell Biology
Uploaded: 2021-12-07T17:43:45-08:00
Duration: 1 min 24 s
Channel: Rabeya Zahid
Description: A protein complex in the nucleus is responsible for transporting mRNA molecules into the cytoplasm. Describe the proteins that form this exporter. What two protein groups are likely behind the mechanism involved in the directional movement of the mRNP and exporter into the cytosol.

   A protein complex in the nucleus is responsible for transporting mRNA molecules into the cytoplasm. Describe the proteins that form this exporter. What two protein groups are likely behind the mechanism involved in the directional movement of the mRNP and exporter into the cytosol.

Molecular Cell Biology

Harvey Lodish,… 7th Edition

Chapter 8, Problem 9

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Solved by Expert Rabeya Zahid

12/07/2021

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A protein complex in the nucleus is responsible for transporting mRNA molecules into the cytoplasm. Describe the proteins that form this exporter. What two protein groups are likely behind the mechanism involved in the directional movement of the mRNP and exporter into the cytosol.

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Key Concepts

ATP-dependent RNA Helicases

ATP-dependent RNA helicases, particularly members of the DEAD-box family such as Dbp5, play a crucial role in the directional movement of mRNPs during the export process. These helicases use the energy derived from ATP hydrolysis to remodel mRNPs as they transit through the nuclear pore, facilitating the release of export factors and ensuring unidirectional transport into the cytoplasm.

mRNA Export Receptors

mRNA export receptors are proteins that recognize and bind mature mRNA molecules to mediate their translocation from the nucleus to the cytoplasm. In many eukaryotes, a heterodimer such as NXF1/TAP and its partner p15/NXT1 serves as the primary export receptor. These proteins bind to the mRNA-protein complexes (mRNPs) and interact with components of the nuclear pore complex, thereby ensuring that only properly processed mRNA is transported to the cytosol.

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