Question

Abnormalities in the number of $X$ chromosomes tends to have milder phenotypic effects than the same abnormalities in autosomes because of _________________. a. deletions b. nonhomologous recombination c. synapsis d. X inactivation

Name: Problem 12, Chapter 13: Biology
Uploaded: 2020-06-03T20:14:15-08:00
Duration: 1 min 1 s
Channel: Fionna Chan
Description: Abnormalities in the number of X chromosomes tends to have milder phenotypic effects than the same abnormalities in autosomes because of . a. deletions b. nonhomologous recombination c. synapsis d. X inactivation

   Abnormalities in the number of $X$ chromosomes tends to have milder phenotypic effects than the same abnormalities in autosomes because of _________________.
a. deletions
b. nonhomologous recombination
c. synapsis
d. X inactivation

Biology

Mary Ann Clark, Jung… 2nd Edition

Chapter 13, Problem 12

Instant Answer

Solved by Expert Fionna Chan

06/03/2020

Step 1

If one of these X chromosomes is abnormal, it may carry a recessive allele. Show more…

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Abnormalities in the number of $X$ chromosomes tends to have milder phenotypic effects than the same abnormalities in autosomes because of _________________. a. deletions b. nonhomologous recombination c. synapsis d. X inactivation

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Key Concepts

X inactivation

X inactivation is an epigenetic process in which one of the two X chromosomes in females is rendered largely transcriptionally inactive. This mechanism, also known as Lyonization, equalizes the expression of X-linked genes between males and females, thereby preventing an overdose of gene products that could lead to abnormal phenotypic consequences when there are extra X chromosomes.

Dosage compensation

Dosage compensation is a broader genetic regulatory system that balances the expression of genes on the sex chromosomes between individuals with different numbers of these chromosomes. In many organisms, including humans, it ensures that the gene products from the X chromosome are produced at similar levels regardless of whether an individual carries one or two X chromosomes, mitigating potential developmental issues that might arise from gene dosage imbalances.

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