Question

An injection contains $50 \mathrm{mg}$ pentobarbital sodium in each $\mathrm{mL}$ of solution. What is the percentage strength $(w / v)$ of the solution?

   An injection contains $50 \mathrm{mg}$ pentobarbital sodium in each $\mathrm{mL}$ of solution. What is the percentage strength $(w / v)$ of the solution?
Essential Math and Calculations for Pharmacy Technicians
Essential Math and Calculations for Pharmacy Technicians
Indra K. Reddy,… 1st Edition
Chapter 3, Problem 16 ↓

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Since the concentration is given as $50 \, \text{mg/mL}$, this means that there are $50 \, \text{mg}$ of pentobarbital sodium in every $1 \, \text{mL}$ of solution.  Show more…

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An injection contains $50 \mathrm{mg}$ pentobarbital sodium in each $\mathrm{mL}$ of solution. What is the percentage strength $(w / v)$ of the solution?
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Key Concepts

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Unit Conversion
Unit conversion is a critical concept when working with measurements, especially in solving concentration problems. In this context, converting milligrams (mg) to grams (g) is necessary because the percentage strength (w/v) is defined as grams per 100 mL. This ensures that the units are consistent and allows for accurate calculations.
Scaling of Concentration
Scaling involves adjusting the concentration measured in one volume (such as 1 mL) to a standard volume (like 100 mL) to ascertain the percentage concentration. By multiplying the measured value by the appropriate factor, one can determine how many grams of solute would be present in 100 mL, thus yielding the weight/volume percentage.
Weight/Volume Percentage Concentration
The weight/volume (w/v) percentage is a common way to denote the concentration of a solution. It expresses the grams of solute present in 100 mL of solution. This concept is widely used in pharmacology, chemistry, and biology to standardize how concentrations are represented, making it easier to compare and prepare solutions consistently.

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Suppose that sodium pentobarbital is used to anesthetize a dog. The dog is anesthetized when its bloodstream contains at least 45 milligrams (mg) of sodium pentobarbital per kilogram of the dog's body weight. Suppose also that sodium pentobarbital is eliminated exponentially from the dog's bloodstream, with a half-life of 5 hours. What single dose should be administered in order to anesthetize a 50-kg dog for 1 hour?

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Pentobarbital Sodium is a drug often used to anesthetize dogs and is known to decay exponentially with a half-life of 5 hours. The dog is anesthetized when its bloodstream contains 45 mg of the drug per kg of the dog's body weight. How much Pentobarbital Sodium needs to be administered at the beginning for a 60 kg dog to prepare for a 3-hour surgery so that it stays anesthetized for the entire surgery period?

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