00:01
Let's talk about ipsps.
00:04
Ips are inhibitory post -synaptic potentials.
00:22
Inhibitory post -synaptic potentials, you can remember, these are the letters of the abbreviation, is when a neurotransmitter binds at an inhibitory synapse, and it reduces the post -synaptic neurons ' ability to generate an action potential.
01:04
So when this neurotransmitter binds at an inhibitory synapse, the post -synaptic neuron really has trouble generating an action potential.
01:14
So ipsp's neurotransmitters reduce the ability of the post -synaptic neuron to generate an action potential.
01:29
It does this usually by hyperpolarization.
01:43
So it hyperpolarizes the post -synaptic membrane.
01:52
And it does so by changing the permeability of the membrane to potassium and chloride.
02:01
So it changes by increasing the permeability of the post -synaptic membrane to either potassium ions, or the cations, or chloride, which is chlorine's anion.
02:25
Sodium permeability is unchanged.
02:38
So when you change the permeability of potassium, so say we have potassium channels open, potassium moves out of the cell.
02:59
So here, let's open a potassium channel.
03:02
Out here is the extracellular fluid...