Question
Anaplerotic reactions permit the citric acid cycle to supply intermediates to biosynthetic pathways while maintaining the proper levels of cycle intermediates. Write the equation for the net synthesis of citrate from pyruvate.
Step 1
This reaction requires ATP and biotin as cofactors. The equation for this reaction is: \[ \text{Pyruvate} + \text{CO}_2 + \text{ATP} + \text{H}_2\text{O} \rightarrow \text{Oxaloacetate} + \text{ADP} + \text{Pi} \] Show more…
Show all steps
Your feedback will help us improve your experience
Bhumika Jayee and 93 other educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Although there is no net synthesis of intermediates by the citric acid cycle, citric acid cycle intermediates are used in biosynthetic reactions such as the synthesis of porphyrins from succinyl-CoA. Write a reaction for the net synthesis of succinyl-CoA from pyruvate.
The first step in the citric acid cycle involves the reaction of acetyl-CoA and oxaloacetate. Show the product of this reaction before hydrolysis to yield citrate.
The citric acid cycle has eight enzymes: citrate synthase, aconitase, isocitrate dehydrogenase, $\alpha$ -ketoglutarate dehydrogenase, succinylCoA synthetase, succinate dehydrogenase, fumarase, and malate dehydrogenase. (a) Write a balanced equation for the reaction catalyzed by each enzyme. (b) Name the cofactor(s) required by each enzyme reaction. (c) For each enzyme determine which of the following describes the type of reaction(s) catalyzed: condensation (carbon-carbon bond formation); dehydration (loss of water); hydration (addition of water); decarboxylation (loss of $\mathrm{CO}_{2}$ ); oxidation-reduction; substrate-level phosphorylation; isomerization. (d) Write a balanced net equation for the catabolism of acetyl-CoA to $\mathrm{CO}_{2}$.
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD