Collagen IV, which occurs in basement membranes, contains a...

Name: Problem 6, Chapter 6: Fundamentals of Biochemistry
Uploaded: 2021-03-22T12:12:43-08:00
Duration: 58 s
Channel: Shazia Naz
Description: Collagen IV, which occurs in basement membranes, contains a sulfilimine bond (colored red in the structure below) that crosslinks two collagen triple helices. Identify the parent amino acid residues that participate in this linkage.

Collagen IV, which occurs in basement membranes, contains a sulfilimine bond (colored red in the structure below) that crosslinks two collagen triple helices. Identify the parent amino acid residues that participate in this linkage.

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Key Concepts

Amino Acid Residues Involved in Crosslinking

The formation of the sulfilimine bond in collagen IV occurs between two specific amino acid residues. One is methionine, which contributes the sulfur atom, and the other is lysine (typically modified post-translationally to hydroxylysine), which provides the nitrogen atom. Their interaction through the sulfilimine bond is crucial for the covalent crosslinking that stabilizes the collagen IV network.

Collagen IV Structure and Basement Membranes

Collagen IV is a distinctive network-forming collagen found primarily in basement membranes. Its organization into an intricate meshwork is vital for the mechanical support and filtering functions of basement membranes, which are essential for tissue structure and function.

Sulfilimine Bond

A sulfilimine bond is a type of covalent linkage characterized by a sulfur-to-nitrogen double bond. This unusual bond plays a critical role in stabilizing protein structures by effectively crosslinking separate polypeptide chains or domains, thereby contributing to the integrity and mechanical strength of the complex protein network.

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