Question

Cystic fibrosis (CF) is a human condition caused by a defect in the cystic fibrosis transmembrane regulator protein (CFTR). Cystic fibrosis is inherited in an autosomal recessive manner. Which is true about CF? a. Heterozygous individuals will have CF. b. Heterozygous individuals make enough normal CFTR for normal cellular function. c. An individual who carries the defective allele will have children with CF. d. None of the above

Name: Problem 2, Chapter 12: Understanding Biology
Uploaded: 2021-09-22T20:39:07-08:00
Duration: 1 min 27 s
Channel: Joanna Quigley

   Cystic fibrosis (CF) is a human condition caused by a defect in the cystic fibrosis transmembrane regulator protein (CFTR). Cystic fibrosis is inherited in an autosomal recessive manner. Which is true about CF?
a. Heterozygous individuals will have CF.
b. Heterozygous individuals make enough normal CFTR for normal cellular function.
c. An individual who carries the defective allele will have children with CF.
d. None of the above

Understanding Biology

Kenneth A. Mason,… 2nd Edition

Chapter 12, Problem 2

Instant Answer

Solved by Expert Joanna Quigley

09/22/2021

Step 1

It is inherited in an autosomal recessive manner. This means that an individual must inherit two copies of the defective gene, one from each parent, to have the disease. Show more…

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Cystic fibrosis (CF) is a human condition caused by a defect in the cystic fibrosis transmembrane regulator protein (CFTR). Cystic fibrosis is inherited in an autosomal recessive manner. Which is true about CF? a. Heterozygous individuals will have CF. b. Heterozygous individuals make enough normal CFTR for normal cellular function. c. An individual who carries the defective allele will have children with CF. d. None of the above

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Key Concepts

Autosomal Recessive Inheritance

This concept involves conditions that require two copies of a mutated gene for the disease to be expressed. In autosomal recessive inheritance, individuals who are heterozygous (carriers) have one normal allele and one defective allele; the normal allele is sufficient to maintain normal function, so carriers typically do not show symptoms of the disease.

Haplosufficiency

Haplosufficiency refers to a situation where a single functional copy of a gene is enough to sustain normal cellular function. In the context of conditions like cystic fibrosis, individuals with one normal allele produce enough of the functional protein to prevent the disease, making them asymptomatic carriers.

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