Question
Describe a computational and an experimental method to identify sequences that act as exonic splicing silencers (ESSs).
Step 1
ESSs are regulatory sequences located within exons that inhibit the splicing of pre-mRNA, thereby affecting the inclusion of specific exons in the final mRNA product. Show more…
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Some exons in the human genome are quite small (less than 75 bp long. Identification of such "microexons" is difficult because these distances are too short to reliably use ORF identification or codon bias to determine if small genomic sequences are truly part of an mRNA and a polypeptide. What techniques of "gene finding" can be used to try to assess if a given region of $75 \mathrm{bp}$ constitutes an exon?
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