00:01
We are doing this crazy cyclization reaction, starting with this micro -acceptor, and also this micro -acceptor.
00:20
So with a strong base, we can deprotonate this alpha position, which of course will come back around and attack this electrophile.
00:35
Of course, at that position, it would not attack directly, but it would add to this.
00:46
Michael position, all right.
00:51
So now we have this carbon bond forming.
01:02
And we have one, two, three, four, five, six, seven.
01:08
Seven membered ring.
01:12
Let me draw these a little bit smaller.
01:23
So this seven membered ring, one, two, three, four, five, six, seven.
01:33
Carbon number seven, now has this, dangling ester group attached.
01:44
7 will go 1, 2, 1.
01:55
On the other side, we still have these metal groups.
02:04
So now we can have our base again deprotonate one of these alpha protons generate our nucleophile, which will come to attack this position...