Question
Explain the fact that protein oligomers (dimers or tetramers) bind more successfully to DNA than monomeric proteins do.
Step 1
Protein oligomers, such as dimers (two subunits) or tetramers (four subunits), have multiple binding sites that can interact with DNA. This multi-subunit structure allows for a greater surface area and more points of contact with the DNA molecule. Show more…
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How is it that protein-protein interactions that are too weak to cause proteins to assemble in solution can nevertheless allow the same proteins to assemble into complexes on DNA?
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