The standard form of an ellipse is $\frac{x^2}{a^2} + \frac{y^2}{b^2} = 1$. To do this, we divide all terms in the given equation by 64:
\[
\frac{16x^2}{64} + \frac{4y^2}{64} = \frac{64}{64}
\]
which simplifies to
\[
\frac{x^2}{4} + \frac{y^2}{16} = 1
\]
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