Question

For preparation of Augmentin (amoxicillin trihydrate and clavulanic acid as a potassium salt) oral suspension, 5 grams of the dry powder should be diluted with $45 \mathrm{~mL}$ of sterile water for injection to obtain a final solution containing $312 \mathrm{mg} / \mathrm{mL}$. If the ratio between amoxicillin trihydrate and clavulanic acid as a potassium salt is $4: 1$, how much of each drug is present in $9 \mathrm{~mL}$ of suspension?

Name: Problem 30, Chapter 11: Essential Math and Calculations for Pharmacy Technicians
Uploaded: 2023-06-14T16:40:42-08:00
Channel: Gayathri Janakiraman Paramasivan
Description: For preparation of Augmentin (amoxicillin trihydrate and clavulanic acid as a potassium salt) oral suspension, 5 grams of the dry powder should be diluted with 45 mL of sterile water for injection to obtain a final solution containing 312 mg / mL. If the ratio between amoxicillin trihydrate and clavulanic acid as a potassium salt is 4: 1, how much of each drug is present in 9 mL of suspension?

   For preparation of Augmentin (amoxicillin trihydrate and clavulanic acid as a potassium salt) oral suspension, 5 grams of the dry powder should be diluted with $45 \mathrm{~mL}$ of sterile water for injection to obtain a final solution containing $312 \mathrm{mg} / \mathrm{mL}$. If the ratio between amoxicillin trihydrate and clavulanic acid as a potassium salt is $4: 1$, how much of each drug is present in $9 \mathrm{~mL}$ of suspension?

Essential Math and Calculations for Pharmacy Technicians

Indra K. Reddy,… 1st Edition

Chapter 11, Problem 30

Instant Answer

Solved by Expert Gayathri Janakiraman Paramasivan

06/14/2023

Step 1

Given that 5 grams of dry powder is diluted with 45 mL of sterile water for injection, the total volume of the final solution will be 5 grams + 45 mL = 50 mL. Show more…

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For preparation of Augmentin (amoxicillin trihydrate and clavulanic acid as a potassium salt) oral suspension, 5 grams of the dry powder should be diluted with $45 \mathrm{~mL}$ of sterile water for injection to obtain a final solution containing $312 \mathrm{mg} / \mathrm{mL}$. If the ratio between amoxicillin trihydrate and clavulanic acid as a potassium salt is $4: 1$, how much of each drug is present in $9 \mathrm{~mL}$ of suspension?

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Key Concepts

Dilution

Dilution is the process of reducing the concentration of a substance within a solution by adding a solvent. This technique is fundamental in pharmaceutical compounding to adjust the potency of medications for appropriate dosing and to achieve a desired final concentration in a given volume.

Ratio and Proportional Reasoning

This key concept deals with breaking down a total quantity into parts that follow a specific ratio, such as 4:1. It is used to determine the individual amounts of components present in a mixture based on their relative proportions, ensuring that each component is present in the correct proportion for efficacy and safety.

Concentration Calculation

This concept involves determining the amount of a substance present per unit volume by dividing the total mass of the substance by the volume of the solution. It is essential in ensuring that the final solution has the correct potency and safety profile, particularly in pharmaceutical preparations where accurate dosing is critical.

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