Question
How do we know that the cap contains 7 -methylguanosine?
Step 1
The cap structure at the 5' end of eukaryotic mRNA is known to be a modified guanine nucleotide, specifically 7-methylguanosine (m7G). Show more…
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The 5'-methyl guanine cap (see figure below) is a post-transcriptional modification that confers stability towards ribonucleases that catalyze 5'->3' hydrolysis of the mRNA transcript. Describe three (3) modifications within the 5'-methyl guanine cap which confer this resistance towards enzymatic degradation.
What is the $5^{\prime}$ cap? How is the $5^{\prime}$ cap added to eukaryotic pre-mRNA? What is the function of the $5^{\prime}$ cap?
Identify structure of Guanine ribonuleotide
Biomolecules
Level I
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