Question
Identify the peak action time of the following types of insulin: rapid-acting regular insulin, intermediate-acting insulin, and long-acting insulin.
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Part 2: Activity of Different Forms of Insulin People with type 1 diabetes may want to take different forms of insulin (Figure 2). For example, rapid-acting insulin could be taken right before a meal to respond to the increase in blood glucose concentration due to eating. This type of insulin is often taken in combination with longer-acting insulin that responds to smaller glucose fluctuations over the course of a day. This change produces the activity profile for insulin detemir shown in the graph in Figure 2 in two ways. First, the formation of dihexamers and stabilization of hexamers caused by this change will decrease the rate of insulin monomer formation. Second, the interaction between insulin monomers and serum proteins will activate the insulin monomers, maintaining the concentration of active insulin monomers in the blood at any time. Then, as the insulin and serum proteins dissociate over time, more active insulin will become available. Figure 2. The action of different types of insulin generated by scientists compared to regular insulin. The period of time over which each type of insulin is active is shown on the x-axis. The activity level of each type of insulin is shown on the y-axis.
Label the following statements about insulin therapy for diabetics as quantitative or qualitative observations: (a) Insulin injections allow a diabetic patient to survive. (b) The peak in the time release profile for natural insulin is 90 minutes while the peak for injected insulin is 150 minutes.
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