Look carefully at the electron micrographs in Figure 18-38 ....

Look carefully at the electron micrographs in Figure $18-38 .$ Describe the differences between the cell that died by necrosis and those that died by apoptosis. How do the pictures confirm the differences between the two processes? Explain your answer.

Key Concepts

Necrosis

Necrosis is a form of cell death resulting from acute injury or stress, which is less controlled than apoptosis. It is marked by cell swelling, loss of membrane integrity, and eventual rupture, leading to the release of cellular contents into the surrounding tissue and often triggering an inflammatory response.

Electron Microscopy

Electron microscopy is an imaging technique that uses a beam of electrons to provide detailed views of the cellular ultrastructure. This high-resolution method allows researchers to visualize the distinct morphological markers of apoptosis and necrosis, thereby confirming the differences between these cell death processes through the observation of features like membrane integrity, nuclear changes, and cellular organization.

Apoptosis

Apoptosis is a form of programmed cell death that is highly regulated and characterized by distinct morphological changes such as cell shrinkage, nuclear condensation, membrane blebbing, and the formation of apoptotic bodies. This process allows cells to die in an orderly manner without triggering an inflammatory response, as the cellular debris is efficiently cleared by phagocytes.

Transcript

00:01 Okay, i want to answer this question, let's talk about the general difference between cell necrosis and apoptosis.

00:07 So cell necrosis is practically a cell death that occurs because of like a external cause, for example, an infection or lack of blood supply to the tissues and other causes.

00:18 Okay, while apoptosis is the type of cell death that is programmed.

00:23 It means the cell wants to die because it knows that there is something wrong inside of it.

00:28 So in order to prevent problems in the tissue or in the organ, the cell is found, they are in the role of apoptosis.

00:37 Okay.

00:38 As you may know or as you may suppose the process of necrosis, as it involves practically an external agent, it is going to cause severe inflammation or inflammation in general, while apoptosis as it is a programmed cell death, then it is going to cause little inflammation.

00:54 Okay? so the question says, to look at this electron micrographs and this kind of differences between the cell that died by necrosis and the cell that died because of apoptosis.

01:10 So in here, in this picture here, we're looking at a cell that is dying because of necrosis.

01:14 Okay, you can see here that the cell membrane, okay, the cell membrane of this cell is guptur.

01:23 And the cell content, that is mainly, member nodes and cytoskeletal debris are seeing or are being spilling into the surrounding through these openings in a cell membrane...

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