RCH2 CH2 OH can be converted to RCH2 CH2 COOH by the following sequence of steps (a) PBr3, KCN,

step 1 In this problem, the reaction can be written as R -CH2 -CH2 -O -H in presence of PBR3. It will c

RCH2 CH2 OH can be converted to RCH2 CH2 COOH by the...

$\mathrm{RCH}_{2} \mathrm{CH}_{2} \mathrm{OH}$ can be converted to $\mathrm{RCH}_{2} \mathrm{CH}_{2}$ COOH by the following sequence of steps (a) $\mathrm{PBr}_{3}, \mathrm{KCN}, \mathrm{H}_{3} \mathrm{O}^{+}$ (b) $\mathrm{HCN}, \mathrm{PBr}_{3}, \mathrm{H}_{3} \mathrm{O}^{+}$ (c) $\mathrm{PBr}_{3}, \mathrm{KCN}, \mathrm{H}_{2} / \mathrm{P}^{+}$ (d) $\mathrm{KCN}, \mathrm{H}_{3} \mathrm{O}^{+}$

$\mathrm{RCH}_{2} \mathrm{CH}_{2} \mathrm{OH}$ can be converted to $\mathrm{RCH}_{2} \mathrm{CH}_{2}$
COOH by the following sequence of steps
(a) $\mathrm{PBr}_{3}, \mathrm{KCN}, \mathrm{H}_{3} \mathrm{O}^{+}$
(b) $\mathrm{HCN}, \mathrm{PBr}_{3}, \mathrm{H}_{3} \mathrm{O}^{+}$
(c) $\mathrm{PBr}_{3}, \mathrm{KCN}, \mathrm{H}_{2} / \mathrm{P}^{+}$
(d) $\mathrm{KCN}, \mathrm{H}_{3} \mathrm{O}^{+}$

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Key Concepts

Alcohol to Alkyl Halide Conversion

This concept involves converting an alcohol into an alkyl halide using reagents like phosphorus tribromide (PBr3). The reaction transforms the poor leaving hydroxyl group into a better leaving group (halide), making the substrate more reactive for subsequent substitution reactions.

Nucleophilic Substitution (SN2) Reaction

In an SN2 reaction, the alkyl halide undergoes a backside attack by a nucleophile, such as the cyanide ion (CN– from KCN), leading to the displacement of the halide. This reaction typically occurs in a single concerted step, resulting in the inversion of configuration at the reaction center.

Nitrile Hydrolysis

Nitrile hydrolysis is the process by which a nitrile group is converted into a carboxylic acid when treated with water under acidic conditions (often using H3O+). This reaction is a valuable method for synthesizing carboxylic acids from nitrile intermediates, expanding the range of accessible functional groups.

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