Multifactorial (complex) diseases a. are less common than...

Multifactorial (complex) diseases
$a$. are less common than single-gene diseases.
$b$. involve the interaction of many genes with the environment.
$c .$ affect less than 1 percent of humans.
$d$. involve the interactions of several mRNAs.
$e$ are exempified by sickle-cell anemia.

Key Concepts

Gene-Environment Interactions

Gene-environment interactions describe the process in which genetic predispositions and external environmental factors combine to influence the onset and severity of a disease. This concept is critical to understanding multifactorial diseases, as the interplay between genes and environmental triggers determines an individual's overall risk and variability in disease presentation.

Polygenic Inheritance

Polygenic inheritance is the mechanism by which multiple genes, often with small individual effects, collectively contribute to the risk of developing a disease. This cumulative effect of many genes is a hallmark of multifactorial diseases and explains why such conditions often have a continuous range of clinical manifestations.

Multifactorial Diseases

This concept refers to diseases that are caused by a combination of multiple genetic factors along with environmental influences. These diseases do not follow a simple Mendelian pattern but rather result from the complex interactions between various genes alongside non-genetic risk factors such as lifestyle or environmental exposures.

Transcript

00:01 For this problem, we are going to be talking a little bit about multifactorial diseases.

00:07 So when we're looking at multifactorial, let's just quickly break down what is actually being said in the term, because from this we can already surmount a large amount of information that will be extremely helpful to solve this problem.

00:22 So when we're talking about a disease that is multifactorial, we have the prefix multi, which means many, more than one, multiple.

00:31 I would just think of, yeah, maybe many is not the most concise word.

00:34 Let's just say more than one.

00:39 So more than one.

00:41 Factorial, we're thinking about factors.

00:43 So we can think about things that play into it or causes.

00:48 That could be a factor for something to occur.

00:50 Causes or i'll just say relevant things to consider.

01:01 Okay.

01:02 So that already gives us a very good understanding and foundation to address this problem.

01:08 Go through the answer options and sort of tease out what would make the most sense because we're looking for the best answer option in this instance in all instances so a they are less common less common than what you may ask less common than single gene diseases now this is simply not true single gene diseases certainly do exist and they should be uh you know studied extensively and considered and should be worried of them of course but the huge thing is that multifactorial, which makes sense, meaning there's many different things that will play into it are much more common.

01:48 So this isn't the right answer.

01:50 Now let's talk about answer option b.

01:52 Now for answer option b involve the interaction of many genes, so with the environment, which makes sense because genes, sometimes the environment can be a factor whether they are expressed or not.

02:07 So you can have the code, you can have the blueprint, and i'm having a bit of a difficulty spelling environment.

02:14 Sorry.

02:15 Environment.

02:17 I'll brief it...

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