Question

$N^{6}$ methylation of adenosine residues is one of the most common mRNA modifications. (a) Draw the structure of the modified base. (b) Would you expect the modification to alter the RNA's ability to form stem-loop structures?

Name: Problem 20, Chapter 26: Fundamentals of Biochemistry
Uploaded: 2021-04-06T13:53:16-08:00
Duration: 3 min 48 s
Channel: Shazia Naz
Description: N^6 methylation of adenosine residues is one of the most common mRNA modifications. (a) Draw the structure of the modified base. (b) Would you expect the modification to alter the RNA's ability to form stem-loop structures?

   $N^{6}$ methylation of adenosine residues is one of the most common mRNA modifications. (a) Draw the structure of the modified base. (b) Would you expect the modification to alter the RNA's ability to form stem-loop structures?

Fundamentals of Biochemistry

Donald Voet, Judith… 5th Edition

Chapter 26, Problem 20

Instant Answer

Solved by Expert Shazia Naz

04/06/2021

Step 1

Step 1: The structure of the modified base, N6-methyladenosine, can be drawn as follows: \[ \begin{array}{c} \text { H } \\ \text { | } \\ \text { H } 2 \text { C } - \text { N } - \text { C } = \text { N } \\ \text { | } \\ \text { H } \\ \end{array} \] Show more…

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$N^{6}$ methylation of adenosine residues is one of the most common mRNA modifications. (a) Draw the structure of the modified base. (b) Would you expect the modification to alter the RNA's ability to form stem-loop structures?

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Key Concepts

N6-Methyladenosine (m6A)

N6-methyladenosine (m6A) is a post-transcriptional modification where a methyl group is added to the nitrogen at the 6th position of the adenine base. This modification is one of the most common in mRNA and plays important roles in regulating RNA stability, splicing, export, and translation. The chemical addition of the methyl group can subtly alter the base's electronic properties and its interactions with proteins and other nucleic acids.

RNA Secondary Structure

RNA secondary structures, such as stem-loop or hairpin structures, form through specific base pairing interactions between complementary nucleotides. Modifications like m6A can affect these structures by altering hydrogen bonding potentials and steric configurations, potentially destabilizing or changing the conformation of the RNA. This, in turn, may influence the molecule’s function and interactions with other biomolecules.

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