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Not all heat shock proteins are chaperones; some are proteins that facilitate the degradation rather than the refolding of other proteins. Explain why the rate of protein degradation would increase during heat shock.
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This increase in temperature can cause proteins to denature or become misfolded. \[ \text{{Temperature increase}} \rightarrow \text{{Protein denaturation or misfolding}} \] Show more…
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Not all heat shock proteins are chaperones; some are proteins that facilitate the degradation rather than the refolding of other proteins. Explain why the rate of protein degradation might be expected to increase during heat shock. Explain what chaperone proteins do in the cell, and why they are necessary. (What would happen if they weren’t around?)
Figure 37.5 Heat shock proteins (HSP) are so named because they help refold misfolded proteins. In response to increased temperature (a theat shock"), heat shock proteins are activated by release from the NR/HSP complex. At the same time, transcription of HSP genes is activated. Why do you think the cell responds to a heat shock by increasing the activity of proteins that help refold misfolded proteins?
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