One issue is whether the Y 402 H gene is in HardyWeinberg...

One issue is whether the $Y 402 H$ gene is in HardyWeinberg equilibrium (HWE). For a gene to be in HWE, its two alleles must assort independently.
Under HWE, what is the expected frequency of the $T C$ genotype among the 1185 subjects in the $A M D=$ no group?

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Key Concepts

Allele Frequencies

Allele frequencies refer to the proportion of different alleles at a specific gene locus in a population. These frequencies are critical for predicting genotype distributions under HWE, as they serve as the building blocks for calculating the expected frequencies of various genotypes.

Heterozygote Genotype Frequency

Under Hardy-Weinberg Equilibrium, the frequency of the heterozygous genotype is calculated using the formula 2pq, where p and q are the frequencies of the two alleles. This formula results from the binomial expansion applied to allele frequencies, reflecting the probability of inheriting one allele from each parent.

Hardy-Weinberg Equilibrium

Hardy-Weinberg Equilibrium (HWE) is a fundamental principle in population genetics that predicts how gene variants (alleles) are transmitted from one generation to the next in an idealized population. In such a population, allele and genotype frequencies remain constant over time provided there is no mutation, migration, selection, or genetic drift, and mating is random.

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