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Order: Diphenhydramine $25 \mathrm{mg}$ IM q6h p.r.n. for itching.
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Order: This is a medication order from a healthcare provider. Show more…
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The breakdown of the antihistamine diphenhydramine is a first order reaction. In children this breakdown has a half-life of 5.3 hours, while in the elderly the half-life for the breakdown of this medication is 11.7 hours. Select children or the elderly for question a and b. a. Determine the value of k, to include a unit, for this medication in either the elderly or for children. Clearly indicate if you have selected children or the elderly. b. (I am making the next part up. You need the answer from a to answer this question) To avoid a potential overdose, a second dose should not be given until the level of diphenhydramine from the first dose has dropped by 80.0%. Continue answering this question for children or the elderly. How many hours would it take for the concentration of diphenhydramine to drop by 80.0% in the population you have selected? c. Assume the same appropriate dose, in mg/kg body weight, of this medication is given to a child and to an older person. A second dose is then taken much earlier than the prescribed amount of time. Who is more likely to experience overdose symptoms, the child or the older person? Explain your answer.
Diphenhydramine, the antihistamine in Benadryl, can be prepared by the following two-step sequence. What is the structure of diphenhydramine?
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