Question
Outline the evidence that shows that editing of the mouse GluR-B transcript by ADAR2 is essential, and that this transcript is the only critical target of ADAR2.
Step 1
ADAR2 (Adenosine Deaminase Acting on RNA 2) is an enzyme that catalyzes the conversion of adenosine (A) to inosine (I) in RNA transcripts, a process known as A-to-I editing. This editing can affect the function of the resulting proteins, particularly in the case Show more…
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