Question
Outline the nonhomologous end-joining mechanism mammals use to repair double-stand DNA breaks. Show how this process can lead to loss of nucleotides at the repair site.
Step 1
This complex binds to the ends of the broken DNA and helps to stabilize the break. Show more…
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Three cellular mechanisms are used to repair double stranded breaks in DNA, Non Homologous End Joining, Homology Dependent Repair, Homologous Recombination. Describe how each of these works and the effect of the outcome of these repairs on the DNA sequence.
The diagrams below show two double-strand break DNA repair pathways: nonhomologous end joining (NHEJ) and homology-directed repair (HDR). Provide a brief explanation for each repair process.
Two pathways, homologous recombination and nonhomologous end joining (NHE)), can repair double-strand breaks in DNA. If homologous recombination is an errorfree pathway whereas NIIE is not always error free, why is NIIE j used most of the time in eukaryotes?
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