00:02
Number 14 says paclatoxyl, a type of taxol, a substance isolated from the pacific u, is effective in the treatment of breast and ovarian cancers.
00:12
It works by stabilizing microtubules, thereby preventing them from disassembling.
00:17
Why would this activity slow or stop the growth of cancer cells? so, paclataxil, which comes from the pacific u, which is an evergreen, actually, it's a medium -sized coniferous tree, is actually involved.
00:33
With stabilizing microtubules.
00:36
So normally when the cells are undergoing mitosis or cellular division, when these chromosomes line up in the phase of metaphase, as i've simulated in this drawing here, where these chromosomes are actually in the middle of the cell, normally what would then happen is this stage would progress to where each of these chromosomes is pulled to either side of the on opposite poles because eventually, as we know, when we get to telophase, these cells are actually going to split into two individual cells.
01:13
And so we would get a copy of each chromosome on each side.
01:16
Well, what happens in the case of pachlaxil is it actually blocks the segregation of these chromosomes.
01:25
And so during mitosis, there's several checkpoints that actually go through and basically proofread or kind of autocorrected.
01:36
If you will, or spell check, if you will, to see if this process is occurring correctly...